Coachella was set to take place next month in the California desert with Rage Against The Machine and Frank Ocean among the headliners.
The event’s organiser Goldenvoice has now postponed it until October, at the request of local health authorities.
Latest figures show the US has more than 1,000 confirmed cases of the disease and 28 deaths.
The Coachella Valley Music and Arts Festival is one of the world’s most high-profile music events with many celebrity attendees.
This year hundreds of acts were set to perform including Travis Scott, Calvin Harris and Lana Del Rey.
Stagecoach, a country music festival organised by the same company, has also been moved from April to October.
“While this decision comes at a time of universal uncertainty, we take the safety and health of our guests, staff and community very seriously,” Goldenvoice said in a statement.
— Coachella (@coachella) March 10, 2020
Coachella will now take place on the weekends of 9, 10 and 11 October and 16, 17 and 18 October, while Stagecoach will be held on 23, 24 and 25 October.
The event organiser said all purchased tickets will be honoured and anyone who bought a ticket will be notified about how to obtain a refund by 13 March.
Coachella attracted some 250,000 attendees last year, while more than 70,000 people went to Stagecoach.