Liverpool will face arch-rivals Manchester United in the Europa League last 16.
Tottenham have been drawn against Bundesliga giants Borussia Dortmund.
Valencia, managed by Gary Neville, will face La Liga rivals Athletic Bilbao, while Sevilla – the winners of the last two Europa League titles – are away to Basel, whose St Jakob-Park ground will host the final.
The games will be played on Thursday, 10 and 17 March.
The winners of the tournament qualify for next season’s Champions League.
Europa League round of 16 draw
Shakhtar Donetsk v Anderlecht
Basel v Sevilla
Villarreal v Bayer Leverkusen
Athletic Bilbao v Valencia
Liverpool v Manchester United
Sparta Prague v Lazio
Borussia Dortmund v Tottenham
Fenerbahce v Braga